Grenade can refer to:
- Grenade (SS:T) - weapon in Serious Sam: Tormental.
- Grenades - ammunition for the MadDog Grenade Launcher, MK III Grenade Launcher and MK IV Grenade Launcher.
- MadDog Grenade Launcher - weapon in Serious Sam: Double D and Serious Sam: Double D: XXL.
- MK III Grenade Launcher - weapon in Serious Sam 1, Serious Sam Classics: Revolution, Serious Sam HD, Serious Sam: Next Encounter, Serious Sam VR and Serious Sam: Xbox.
- MK IV Grenade Launcher - weapon in Serious Sam 2.
- RB-45 Hand Grenade - throwable weapon in Serious Sam 2.
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